IMR Press / FBL / Volume 13 / Issue 15 / DOI: 10.2741/3110

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Modulating HIV-1 RNA processing and utilization
Show Less
1 Department of Molecular Genetics, University of Toronto, Toronto, Ontario

*Author to whom correspondence should be addressed.

Academic Editor: Zhi-Ming Zheng

Front. Biosci. (Landmark Ed) 2008, 13(15), 5693–5707; https://doi.org/10.2741/3110
Published: 1 May 2008
(This article belongs to the Special Issue Protein-RNA interactions in viral RNA processing)
Abstract

Expression of the integrated HIV-1 provirus is achieved by overcoming multiple barriers to the processing, transport and utilization of the viral RNA. Some of the strategies involve viral encoded proteins (i.e. Rev, Gag). However, in large part it is host factors that play essential roles in the movement of HIV-1 RNA from the site of transcription to its ultimate encapsidation into new virions. Identifying these factors and their mechanism of action provides not only important insights into HIV-1 molecular biology but also that of the cell machinery itself. In this review, we highlight the viral and host factors regulating the splicing, polyadenylation, transport, and translation of HIV-1 RNA. The observations made underline the multiple fate decisions that must be made at each stage of the viral RNA metabolic pathway and highlight potential new avenues for controlling HIV-1 replication.

Share
Back to top