IMR Press / FBL / Volume 13 / Issue 13 / DOI: 10.2741/3068

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS
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1 Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore MD 21287

*Author to whom correspondence should be addressed.

Academic Editor: Francesca Peruzzi

Front. Biosci. (Landmark Ed) 2008, 13(13), 5120–5130; https://doi.org/10.2741/3068
Published: 1 May 2008
(This article belongs to the Special Issue Molecular basis of neuronal dysfunction in AIDS)
Abstract

Sphingolipids are a class of lipids enriched in the central nervous system that have important roles in signal transduction. Recent advances in our understanding of how sphingolipids are involved in the control of life and death signaling have uncovered roles for these lipids in the neuropathogenesis of HIV-associated neurocognitive disorders (HAND). In this review we briefly summarize the molecular mechanisms involved in the pathological production of the toxic sphingolipid, ceramide and address questions of how cytokine and cellular stress pathways that are perturbed in HAND converge to deregulate ceramide-associated signaling.

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