IMR Press / FBL / Volume 13 / Issue 11 / DOI: 10.2741/3010

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Evolutionary constraints imposed by gene dosage balance

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1 Department of Ecology and Evolution, University of Chicago, IL, 60637, USA
2 Department of Bioengineering, Rice University, Houston, TX, 77005, USA, Department of Computer Science, University of Chicago, Chicago, IL, 60637, USA

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Landmark Ed) 2008, 13(11), 4373–4378; https://doi.org/10.2741/3010
Published: 1 May 2008
Abstract

The gene dosage balance hypothesis states that a concentration imbalance among components of macromolecules is often deleterious. Thus this notion potentially provides a mechanistic explanation for understanding genetic dominance and gene duplicability. Accumulating evidence emerged from recent genomic data has strongly supported this hypothesis. Further efforts are needed to understand dosage sensitivity in the context of organismal complexity and co-regulation of genes under dosage-balance constraints.

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