IMR Press / FBL / Volume 12 / Issue 9 / DOI: 10.2741/2333

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Discovery of new peptides from old prohormones: insights for energy balance and beyond
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1 Division of Endocrinology, Department of Medicine Brown Medical School/Rhode Island Hospital, and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02903, USA
2 Department of Microbiology and Molecular Genetics, Harvard Medical School, Microbiology-Armenise, Boston, MA 02115, USA
Front. Biosci. (Landmark Ed) 2007, 12(9), 3545–3553;
Published: 1 May 2007

A complex network of peptide hormones secreted from the gut, adipose tissue, the brain, and other tissues regulate energy balance. Intensive investigation has uncovered the role of many of the major players in energy balance. However, many of these peptide hormones are derived from precursor proteins whose in vivo processing have not been fully studied. In this review we highlight the importance of fully understanding the processing of prohormones and highlight a particular case of why this is important with the recent discovery of the peptide obestatin.

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