IMR Press / FBL / Volume 12 / Issue 9 / DOI: 10.2741/2330

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Hypoxia and prognosis: the oxygen tension mounts
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1 Department of Radiation Oncology, William Beaumont Hospital, MI, USA
Academic Editors:Olga Greco, Simon Scott
Front. Biosci. (Landmark Ed) 2007, 12(9), 3502–3518; https://doi.org/10.2741/2330
Published: 1 May 2007
(This article belongs to the Special Issue The tumor microenvironment as a target for therapy)
Abstract

Hypoxia has been the subject of research within the radiotherapy community for many years. Until relatively recently, reliable methods to measure hypoxia were unavailable. However since the 1990's, a series of different methodologies have been developed which have allowed large-scale studies of the prognostic significance of this tumor-associated process. Within the same time-frame biological knowledge concerning hypoxia has dramatically increased and a paradigm shift has taken place in current thinking concerning the role of hypoxia not only in treatment resistance but also as a driving force in malignant progression and continued tumor growth. This review discusses the current view of hypoxia, the methods available to measure hypoxia and the prognostic information that has been attained.

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