IMR Press / FBL / Volume 12 / Issue 5 / DOI: 10.2741/2200

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Electrochemical studies oxidation of ciprofloxacin at nano-SnO2/PVS modified electrode and its interaction with calf thymus DNA

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1 College of Chemistry and Materials Science, Anhui Key Laboratory of Functional Molecular Solids Anhui Normal University, Wuhu 241000, PR China
Front. Biosci. (Landmark Ed) 2007, 12(5), 1946–1955;
Published: 1 January 2007

In pH 6.0 phosphate buffer solutions (PBS), a glassy carbon electrode (GCE) modifying by nano-tin oxide/polyvinyl sulfonic potassium (nano-SnO2/PVS) exhibited an enhanced effectiveness for the oxidation of ciprofloxacin (CFX), which compared with a bare GCE or a nano-SnO2 modified electrode. In addition we also investigated the electrooxidation mechanism of the fluoroquinolone antibiotics (utilizing ciprofloxacin, ofloxacin, sparfloxacin and lomefloxacin) at the modified electrode. Furthermore, gel electrophoresis coupled with electrochemistry and spectra techniques were used to study the interaction of CFX and calf thymus DNA (ctDNA). These acquired data showed that the binding mode of CFX and DNA was mainly an intercalation mechanism.

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