IMR Press / FBL / Volume 12 / Issue 2 / DOI: 10.2741/2086

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease
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1 School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia
Academic Editor:Alister Ward
Front. Biosci. (Landmark Ed) 2007, 12(2), 608–618; https://doi.org/10.2741/2086
Published: 1 January 2007
(This article belongs to the Special Issue GCF and ts receptor)
Abstract

Granulocyte colony-stimulating factor (G-CSF) is a key regulator of granulopoiesis via stimulation of a specific cell-surface receptor, the G-CSF-R, found on hematopoietic progenitor cells as well as neutrophilic granulocytes. It is perhaps not surprising, therefore, that mutations of the G-CSF-R has been implicated in several clinical settings that affect granulocytic differentiation, particularly severe congenital neutropenia, myelodysplastic syndrome and acute myeloid leukemia. However, other studies suggest that signalling via the G-CSF-R is also involved in a range of other malignancies. This review focuses on the molecular mechanisms through which the G-CSF-R contributes to disease.

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