IMR Press / FBL / Volume 12 / Issue 2 / DOI: 10.2741/2073

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The role of actomyosin and the microtubular network in both the immunological synapse and T cell activation
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1 Servicio de Inmunologia, Hospital Universitario de La Princesa, C/ Diego de Leon, 62, 28006-Madrid, Spain
Academic Editor:Antonio Sechi
Front. Biosci. (Landmark Ed) 2007, 12(2), 437–447; https://doi.org/10.2741/2073
Published: 1 January 2007
Abstract

The formation of immunological synapses between T cells and APCs, as well as the functions associated with this structure, like cytokine secretion and the lysis of infected cells, are critical processes in the immune response. The T cell cytoskeleton is involved in these activities and this has been the subject of numerous studies in recent years. Although the importance of the T cell actin network is evident, the participation of microtubules and myosin motors in the formation of immunological synapses and T cell effector functions has also been assessed. This review provides an update on the role of cytoskeletal networks and related molecules in the activation of T lymphocytes.

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