IMR Press / FBL / Volume 12 / Issue 13 / DOI: 10.2741/2427

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Slipped strand DNA structures
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1 Laboratory of DNA Structure and Mutagenesis, Department of Biological Sciences, Florida Institute of Technology, 150 West University Blvd., Melbourne, FL 32901-6975, USA
2 Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, 2121 West Holcombe Blvd., Houston, TX 77030-3303, USA
Academic Editor:Sergei Mirkin
Front. Biosci. (Landmark Ed) 2007, 12(13), 4788–4799; https://doi.org/10.2741/2427
Published: 1 September 2007
(This article belongs to the Special Issue DNA structures, genome instability and human disease)
Abstract

Slipped strand DNA structures are formed when complementary strands comprising direct repeats pair in a misaligned, or slipped, fashion along the DNA helix axis. Although slipped strand DNA may form in almost any direct repeat, to date, these structures have only been detected in short DNA repeats, termed unstable DNA repeats, in which expansion is associated with many neurodegenerative diseases. This alternative DNA structure, or a similar slipped intermediate DNA that may form during DNA replication or repair, may be a causative factor in the instability of the DNA sequences that can form these structures.

Keywords
Slipped Strand DNA
DNA Repeats
Triplet Repeats
Unstable DNA repeats
DNA structure
Alternative DNA Conformations
Neurodegenerative Diseases
Review
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