IMR Press / FBL / Volume 12 / Issue 12 / DOI: 10.2741/2424

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Evidence for a role of nicotinic acetylcholine receptors in schizophrenia
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1 Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, USA
2 Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
Academic Editor:Ursula Winzer-Serhan
Front. Biosci. (Landmark Ed) 2007, 12(12), 4755–4772; https://doi.org/10.2741/2424
Published: 1 May 2007
(This article belongs to the Special Issue Nicotinic acetylcholine receptors in adult and developing brain)
Abstract

Schizophrenia is a debilitating, complex and costly illness affecting roughly 1% of the world's inhabitants. The excessive degree of cigarette smoking exhibited by schizophrenic patients suggests that they might be self-medicating to ameliorate certain aspects of the characteristic positive, negative and cognitive symptoms associated with the disease. Morphological examinations found alterations in nicotinic receptors in postmortem tissue from schizophrenic individuals compared to controls, especially in the α7 and α4β2 subtypes. These data were consistent with molecular biology studies which demonstrated associations between polymorphisms in gene coding for these receptors and schizophrenia. In studies of nicotinic receptor stimulation in schizophrenia patients, improvement in sensory inhibition and cognitive deficits were observed following treatment, though the effects were transient. These results have spurred the development of new pharmaceuticals specifically designed to modulate nicotinic receptor function. The initial results from clinical trials of these new drugs appear promising, potentially opening new avenues of treatment for this devastating disease.

Keywords
Brain
Schizophrenia
Smoking
Nicotinic receptors
Review
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