IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2373

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism
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1 Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, Department of Radiology, University of California San Francisco, San Francisco, CA, USA
Academic Editor:Randall Davis
Front. Biosci. (Landmark Ed) 2007, 12(11), 4079–4100; https://doi.org/10.2741/2373
Published: 1 May 2007
(This article belongs to the Special Issue Neuroinflammation: modulation by drugs of abuse)
Abstract

Chronic cigarette smoking is associated with adverse effects on cardiac, pulmonary, and vascular function as well as the increased risk for various forms of cancer. However, little is known about the effects of chronic smoking on human brain function. Although smoking rates have decreased in the developed world, they remain high in individuals with alcohol use disorders (AUD) and other neuropsychiatric conditions. Despite the high prevalence of chronic smoking in AUD, few studies have addressed the potential neurobiological or neurocognitive consequences of chronic smoking in alcohol use disorders. Here, we review the the neurobiological and neurocognitive findings in both AUD and chronic cigarette smoking, followed by a review of the effects of comorbid cigarette smoking on neurobiology and neurocognition in AUD. Recent research suggests that comorbid chronic cigarette smoking modulates magnetic resonance-detectable brain injury and neurocognition in alcohol use disorders and adversely affects neurobiological and neurocognitive recovery in abstinent alcoholics.. Consideration of the potential separate and interactive effects of chronic smoking and alcohol use disorders may have significant implications for pharmacological and behavioral treatment interventions.

Keywords
alcoholism
alcohol use disorders
cigarette smoking
cognition
magnetic resonance imaging
magnetic resonance spectroscopy
neurocognition
neuroimaging
perfusion
recovery
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