IMR Press / FBL / Volume 12 / Issue 1 / DOI: 10.2741/2066

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Magnesium homeostasis in mammalian cells
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1 Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA
Academic Editor:Michael Maguire
Front. Biosci. (Landmark Ed) 2007, 12(1), 308–331;
Published: 1 January 2007

Mammalian cells tightly regulate cellular Mg2+ content despite undergoing a variety of hormonal and metabolic stimulatory conditions. Evidence from several laboratories indicates that stimulatory conditions that increase cellular cAMP level result in a major mobilization of Mg2+ from cells and tissues into the bloodstream. Conversely, hormones or agents that decrease cAMP level or activate protein kinase C signaling induce a major accumulation of Mg2+ into the tissues. These Mg2+ fluxes are quite large and fast suggesting the operation of powerful transport mechanisms. At front of the recent identification of several Mg2+ entry mechanisms, the Mg2+ extrusion pathway(s) still remain(s) poorly characterized. Similarly, it remains not completely elucidated the physiological significance of these Mg2+ fluxes in the various tissues in which they occur. In the present review, we will attempt to provide a comprehensive framework of the modalities by which cellular Mg2+ homeostasis and transport are regulated, as well as examples of cellular functions regulated by changes in cellular Mg2+ level.

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