IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/1990

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Mitochondrial Ca2+ transport, permeability transition and oxidative stress in cell death: implications in cardiotoxicity, neurodegeneration and dyslipidemias

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1 Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, 13083-970, Brazil
2 Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, 05508-900, Brazil
3 Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, 13083-970, Brazil
Front. Biosci. (Landmark Ed) 2006, 11(3), 2554–2564; https://doi.org/10.2741/1990
Published: 1 September 2006
Abstract

Mitochondrial Ca2+ transport is important in the maintenance of intracellular ion homeostasis, and also a key factor in the pathogenesis of many diseases. We discuss here the main aspects of mitochondrial Ca2+ transport, and how this transport is linked to changes in energy metabolism and redox state. Mitochondrial permeability transition, a consequence of excessive mitochondrial Ca2+ accumulation associated with oxidative stress is also discussed. Finally, our current understanding of the involvement of these mitochondrial processes in cardiac ischemia-reperfusion, neurodegeneration and dyslipidemias is presented.

Keywords
Mitochondria
Calcium
Potassium
Free Radicals
Apoptosis
Necrosis
Stroke
Heart Attack
Dyslipidemia
Review
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