IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/1978

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cell adhesion molecules at the synapse
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1 Department of Psychiatry, University of British Columbia, Vancouver, B.C., Canada
Academic Editor:Michael Hortsch
Front. Biosci. (Landmark Ed) 2006, 11(3), 2400–2419; https://doi.org/10.2741/1978
Published: 1 September 2006
(This article belongs to the Special Issue Neural cell adhesion molecules)
Abstract

Synapses are specialized intercellular junctions whose specificity and plasticity provide the structural and functional basis for the formation and maintenance of the complex neural network in the brain. The number, location, and type of synapses formed are well controlled, since synaptic circuits are formed in a highly reproducible way. This implies the existence of cellular and molecular properties that determine the connectivity of each neuron in the nervous system. Recent evidence has elucidated that these key features of the synapse are regulated by several families of cell-adhesion molecules (CAMs) enriched at synaptic junctions, including neuroligins, SynCAM, NCAM, L1-CAM, cadherins, protocadherins, and integrins. In this review we will discuss the various stages of synaptogenesis from the perspective of CAMs: Contact initiation, recruitment of presynaptic and postsynaptic proteins, synapse maturation/stabilization or elimination, and synaptic plasticity. We will also highlight some of the factors that regulate the function of these CAMs at the synapse, and discuss how dysfunction of these adhesive systems may contribute to several neurological disorders.

Keywords
Synapse Formation
Adhesion
CNS
Central Nervous System
NMJ
Review
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