IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/1960

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Stress-induced hyperalgesia: animal models and putative mechanisms
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1 Department of Oral Anatomy, Osaka Dental University, Kuzuhahanazono-cho 8-1, Hirakata City, 573-1121, Japan
2 Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811-1, Wakayama City, 641-8509, Japan
Front. Biosci. (Landmark Ed) 2006, 11(3), 2179–2192;
Published: 1 September 2006

Stress has been shown to affect brain activity and promote long-term changes in multiple neural systems. A variety of environmental and/or stressful stimuli have been shown to produce analgesia, a phenomenon often referred to as stress-induced analgesia (SIA). However, acute and chronic stresses also produce hyperalgesia in various behavioral tests. There are now several animal models in which stress enhances nociceptive responses. The dysfunction of the hypothalamo-pituitary-adrenocortical axis (HPA axis) and multiple neurotransmitter systems in the central nervous system (CNS), including endogenous opioid, serotonergic and noradrenergic systems, has been reported. These stress-induced hyperalgesia models may contribute to a better understanding of chronic pain and provide a more rational basis for drug therapies in a variety of pain syndromes.

Chronic stress
Chronic pain
Stress-induced hyperalgesia
HPA axis
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