IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1854

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Genes differentially expressed in responsive and refractory acute leukemia
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1 State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, P.R. China
2 Hematology Department, Changhai Hospital, The Second Military Medical University, Shanghai 200433 China
3 Shanghai BioStar Genechip Institute, Shanghai 200092, P.R. China
Front. Biosci. (Landmark Ed) 2006, 11(1), 977–982; https://doi.org/10.2741/1854
Published: 1 January 2006
Abstract

DNA microarray in 22 patients with acute leukemia revealed genes which were differentially expressed. Ribosomal protein SA (RPSA), minichromosome maintenance deficient 2 (MCM2) and heterogeneous nuclear ribonucleoprotein A1 (HNRPA1) were significantly upregulated (p<0.05, t test) in refractory patients, suggesting that they may play a role in refractoriness in acute leukemia and could be biomarkers of prognosis.

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