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Article
Genes differentially expressed in responsive and refractory acute leukemia
Qing Wei1, Yao Li1, Li Chen2, Liying Zhang1, Xianmin He3, Xuping Fu1, Kang Ying1, Jianfeng Huang3, Qin Chen3, Yi Xie1, Yumin Mao1,*
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1
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, P.R. China
2
Hematology Department, Changhai Hospital, The Second Military Medical University, Shanghai 200433 China
3
Shanghai BioStar Genechip Institute, Shanghai 200092, P.R. China
Front. Biosci. (Landmark Ed) 2006, 11(1), 977–982;
https://doi.org/10.2741/1854
Published: 1 January 2006
Abstract
DNA microarray in 22 patients with acute leukemia revealed genes which were differentially expressed. Ribosomal protein SA (RPSA), minichromosome maintenance deficient 2 (MCM2) and heterogeneous nuclear ribonucleoprotein A1 (HNRPA1) were significantly upregulated (p<0.05, t test) in refractory patients, suggesting that they may play a role in refractoriness in acute leukemia and could be biomarkers of prognosis.