IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1849

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Advances in malignant melanoma: genetic insights from mouse and man
Show Less
1 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
2 Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02115, USA
Front. Biosci. (Landmark Ed) 2006, 11(1), 928–942;
Published: 1 January 2006

Notorious for its proclivity for metastases and resistance to known therapies, malignant melanoma represents a major health concern. Genetic, epidemiological and genomic investigations are highlighting a repertoire of stereotypical mutations that are associated with human melanoma genesis. The functional significance of many of these genetic alterations is being ascertained through the use of in vivo mouse models. Insights from human and mouse studies, coupled with the development of novel tools for high-resolution characterization of the melanoma genome, hold promise for the identification of better diagnostic markers and potential therapeutic targets. With the rapid improvements in drug design, these recent advances are generating optimism for the development of better therapeutic options for melanoma patients.

Back to top