IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1828

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
The application of HSP70 as a target for gene therapy
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1 Dept. of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, Neurology (127), 4150 Clement St., San Francisco, CA 94121
Front. Biosci. (Landmark Ed) 2006, 11(1), 699–707; https://doi.org/10.2741/1828
Published: 1 January 2006
Abstract

The 70-kDa heat shock proteins (HSP70s) are well-studied and characterized heat shock proteins (HSPs). They constitute essential components of a quality control system of protein synthesis, and function as molecular chaperones to prevent proteins from misfolding and aggregating during both de novo synthesis and under conditions of stress. Moreover, it is now well established that HSP70s play important cytoprotective roles in various pathological settings. Recognition of molecular chaperone and cytoprotective functions of HSP70s is fostering active investigations into the potential of HSP70s as therapeutic targets at the laboratory level. Gaining insight into these recent advances may have profound implications in the development of HSP70-based clinical studies.

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