Stem cells for cardiac repair: state of the art

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Gianluigi Condorelli^1,3,*, Cesare Peschle^2,4

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¹ Laboratory of Molecular Cardiology, San Raffaele Biomedical Science Park and Multimedica Hospital, Milan, Italy

² Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy

³ Institute of Molecular Medicine, University of California San Diego, Philadelphia, PA, USA

⁴ Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA, USA

Academic Editor: Vicente Andres

Front. Biosci. (Landmark Ed) 2005, 10(3), 3143–3150;

Published: 1 September 2005

(This article belongs to the Special Issue Genetically-modified animals as research models in development and disease)

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Abstract

Stem cell research has generated great excitement over the last few years. In cardiovascular medicine, the possibility to cure heart failure with newly generated cardiomyocytes (CMCs) has sparked the interest of many scientists; as a result, different "ideal" cardiac stem cells were proposed for therapeutic use. We review here the literature in the cardiac stem cell field, which sometimes is "dialectic" in methodology and results.

Keywords

Heart

Cardiac

Stem Cell

Heart Failure

Differentiation

Review

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