IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1765

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Apoptosis in alcoholic and nonalcoholic steatohepatitis
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1 Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, USA
2 Department of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN

Academic Editor: Nobuhiro Sato

Front. Biosci. (Landmark Ed) 2005, 10(3), 3093–3099; https://doi.org/10.2741/1765
Published: 1 September 2005
(This article belongs to the Special Issue Non alcoholic fatty liver disease NAFLD)
Abstract

Alcohol liver disease (ALD) as well as nonalcoholic fatty liver disease (NAFLD) are two of the most common forms of chronic liver disease worldwide and may progress to cirrhosis and end stage liver disease. ALD and NAFLD seem to share many pathophysiologic mechanisms with the accumulation of lipids in the liver being the first step in the development of both conditions. While mitochondrial dysfunction and production of reactive oxygen species seem to play an important role in the progression from simple steatosis to steatohepatitis in both diseases, the pathogenesis of ALD and NAFLD as it relates to tissue injury remains poorly understood. Insights into these mechanisms are of significant clinical importance because current therapies for both conditions are limited and future therapies will be predicated by an understanding of their pathogenesis. In this review we focused on the current evidence for a central role of hepatocellular apoptosis, a specific form of cell death, in the pathogenesis of ALD and NAFLD as well as the current knowledge regarding the subcellular and molecular mechanisms involve in triggering hepatocyte apoptosis in these diseases.

Keywords
Bax
Lipoapoptosis
Fatty Acid
Apoptosis
Alcohol
Liver
Hepatocyte
Review
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