IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1739

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Defects in ankyrin-based cellular pathways in metazoan physiology
Show Less
1 Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
2 Howard Hughes Medical Institute and Departments of Cell Biology, Biochemistry, and Neurosciences, Duke University Medical Center; Durham, NC 27710

Academic Editor: Philippe Gascard

Front. Biosci. (Landmark Ed) 2005, 10(3), 2832–2840;
Published: 1 September 2005

Ankyrins are a ubiquitously expressed family of membrane-adaptor proteins found in most vertebrate tissues. Since the first ankyrin polypeptide was identified over 25 years ago (1), studies in humans, mice, and lower organisms have implicated critical roles for ankyrins in normal metazoan physiology. This review will provide an overview of the ankyrin family and highlight seminal findings in the field which have linked dysfunction in ankyrin-based pathways with defects in metazoan physiology and human disease.

long QT
Sudden Cardiac Death
Back to top