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Article
Inflammation-dependent thrombosis
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1
Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, MI 48109-0654, USA
2
Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor, MI
Front. Biosci. (Landmark Ed) 2005, 10(3), 2750–2757;
https://doi.org/10.2741/1732
Published: 1 September 2005
Abstract
Vessel wall endothelial damage initiates a local inflammatory response, which promotes a prothrombotic state driven by tissue factor, adhesion molecules, and pro-inflammatory cytokines. Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis.
Keywords
Inflammation
Thrombosis
Vascular Disease
Inflammatory Mediators
Thrombogenesis
Tissue Factor
Adhesion Molecules
Microparticles
Review