IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1721

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Human genome  – from pieces to patterns

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1 NCSV, MAE, Nanyang Technological University, 639798, Singapore
2 Department of Microbiology, National University of Singapore, Singapore 119260
3 Department of Medicine, University of Alabama at Birmingham, 796 Birmingham, AL 35294- 0005, USA
4 BioInformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671
Front. Biosci. (Landmark Ed) 2005, 10(3), 2576–2584; https://doi.org/10.2741/1721
Published: 1 September 2005
Abstract

A profile of exon-intron lengths in genes shows a normal distribution. This observation suggests that different genes may have portions of their total exon and/or intron lengths in common. In order to explore the common exon-intron structural patterns that may arise due to common lengths across genes, we compared the exon-intron length patterns of annotated human genes. We discovered 1762278 conserved arrangements of exon-intron length across the otherwise unrelated and diverse genomic landscape. The existence of common exon-intron length patterns across unrelated genes suggests for their role of in gene assemblage and human genome design and architecture.

Keywords
Exon-Intron Length Patterns
Human Genome
Block Length
Duplication
Genome Design
Gene Architecture
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