IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1622

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Microdialysis - an in vivo technique for studies of growth factors in breast cancer

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1 Division of Gynecologic Oncology, Faculty of Health Sciences, University Hospital, SE-581 85 Linköping, Sweden

Academic Editor: Sushanta K. Banerjee

Front. Biosci. (Landmark Ed) 2005, 10(2), 1329–1335; https://doi.org/10.2741/1622
Published: 1 May 2005
(This article belongs to the Special Issue Growth factors and cancer)
Abstract

Changes in the microenvironment are important in the development of cancer and further tumor growth. Although landmark discoveries have been made regarding genetic alterations in cancer at a cellular level very little is known about protein regulation in the extracellular space. In the microenvironment many growth factors are activated at a post-translational level by interactions of different cell types such as epithelial cells, fibroblasts, adipose cells, and immune cells. The extracellular space is the bioactive site for the majority of growth factors and increased knowledge of protein activation in this compartment is of utmost importance for our comprehension of tumor biology. Microdialysis is a minimally invasive technique, which enables sampling of molecules in the extracellular space. It is applicable in human cancer as well as in experimental tumors. This review describes microdialysis, its application and the up to date literature of microdialysis for detection of growth factors in cancer with special emphasis on breast cancer.

Keywords
Microdialysis
Growth Factors
IGF-1
VEGF
cytokines
cathepsin D
Gene
Review
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