IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1597

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Organizing a tête-à-tête between cell adhesion molecules and extracellular proteases: a risky business that could lead to the survival of tumor cells
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1 INRS-Institut Armand-Frappier, University of Québec, Laval, Canada, H7V 1B7

Academic Editor: George Blanck

Front. Biosci. (Landmark Ed) 2005, 10(2), 1040–1049; https://doi.org/10.2741/1597
Published: 1 May 2005
(This article belongs to the Special Issue Tumor cell regulation of the immune system)
Abstract

Several membrane-bound molecules expressed at the surface of tumor cells have been shown to be released in a soluble form, thereby affecting cell-cell interactions by reduction of ligand densities. Moreover, since the binding domain of the soluble molecules often remains functional, proteolytic cleavage can also reduce the recognition of tumor cells by effector cells bearing the corresponding receptor. Proteolytic cleavage of cell adhesion molecules (CAMs) at the surface of stromal cells, most notably at the surface of vascular endothelial cells, can also limit the recruitment of effector cells at tumor sites. It is noteworthy that, in most cases, the signals that regulate the expression of extracellular proteases are mediated by the same adhesion molecules than those that are targeted by the proteases, suggesting that there is an intimate relationship between extracellular proteases and cell surface adhesion molecules. In this review, we will discuss the functional relationship between CAMs and proteases and how this may lead to tumor evasion.

Keywords
Cancer
Adhesion Molecule
Icam-1
Protease
Matrix Metalloprotease
Immunosurveillance
Homing
Gene
Review
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