IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1594

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
CCN proteins and cancer: two to tango
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1 Université Paris 7-D.Diderot, Laboratoire d Oncologie Virale et Moléculaire, 2 place Jussieu, Case 7048, 75251 Paris Cedex France

Academic Editor: Sushanta K. Banerjee

Front. Biosci. (Landmark Ed) 2005, 10(2), 998–1009; https://doi.org/10.2741/1594
Published: 1 May 2005
(This article belongs to the Special Issue Growth factors and cancer)
Abstract

The CCN genes encode secreted proteins, associated to the extracellular matrix. They are involved in diverse biological processes such as regulation of cell- adhesion, migration, proliferation, differentiation and survival. They play important roles in pregnancy, development, angiogenesis, wound repair and inflammation. Several lines of evidence support a role for CCN genes in fibrotic disorders and tumorigenesis. We will focus our attention in this review on two CCN proteins: CCN1 and CCN3, that appear to exert distinct and opposite effects. Recent data suggest that CCN1 acts as a tumor-promoting factor and a key regulator in cancer progression, while CCN3 exhibits suppressive capabilities. The possible opposite functions of CCN1 and CCN3 in tumorigenesis, and the relevance of the distinct expression profiles of these two genes observed in many cancers are discussed below.

Keywords
CCN protein
CCN3-NOV
CCN1-Cyr61
cancer
tumorigenesis
cell growth regulator
Gene
Review
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