IMR Press / FBL / Volume 10 / Issue 1 / DOI: 10.2741/1580

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Histone modifications as key regulators of transcription
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1 Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002 India
2 Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry New Jersey, 683 Hoes lane West, Piscataway NJ 08854, USA
Front. Biosci. (Landmark Ed) 2005, 10(1), 866–872; https://doi.org/10.2741/1580
Published: 1 January 2005
Abstract

Covalent modifications of the amino-termini of the core histones in nucleosomes have been shown to be one of the key regulatory mechanisms in transcription regulation. Recently, new roles for histone modifications have been uncovered for the efficient functioning of RNA Pol II. Besides acetylation, which is the most characterized to date these modifications comprise phosphorylation, methylation, and ubiquitination. This review gives comprehensive view of all the major histone modifications and their effect on transcriptional regulation, in Saccharomyces cerevisiae.

Keywords
RNA Polymerase II
Histone modification
Transcription regulation
Review
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