IMR Press / FBL / Volume 1 / Issue 5 / DOI: 10.2741/A147

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Application of sperm antigens in immunocontraception
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1 Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43699, USA
Academic Editor:Rajesh K. Naz
Front. Biosci. (Landmark Ed) 1996, 1(5), 87–95;
Published: 1 September 1996
(This article belongs to the Special Issue Male reproductive medicine)

Development of a vaccine(s) based on sperm antigens represents a promising approach for contraception. The utility of an antigen in immunocontraception is contingent upon its tissue specificity, involvement in human fertility, and immunogenicity. A number of antigens have been characterized from the sperm surface. Notable among these are LDH-C4, RSA antigens, PH-20, SP 1U, HSA-63, FA-1, FA-2 and CS-1. These antigens have been proposed as potential candidates for the development of contraceptive vaccine(s). Their current status, application, relative merits, and immunogenicity in immunocontraception are discussed in this review.

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