IMR Press / FBL / Volume 1 / Issue 5 / DOI: 10.2741/A144

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Methods for enhancement of sperm function
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1 Assisted Reprodutive Technology, The Center for Human Reproduction, 750 North Orleans, Chicago, IL 60610
2 Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Florida College of Medicine, Pensacola, FL 32503
Academic Editor:Rajesh K. Naz
Front. Biosci. (Landmark Ed) 1996, 1(5), 65–71; https://doi.org/10.2741/A144
Published: 1 August 1996
(This article belongs to the Special Issue Male reproductive medicine)
Abstract

From a review of recent advances in human reproduction, it is apparent that therapeutic approaches to male infertility have been revolutionized. While our understanding of sperm function at the molecular level is steadily increasing, the realization of consistent oocyte fertilization by mechanically bypassing natural barriers has given new perspective for future investigation. This chapter reviews current knowledge of adjuvants that enhance sperm function and lend themselves to clinical application. Each compound is presented with recent publications supporting proposed mechanisms of action. Specifically, follicular fluid, progesterone, pentoxifylline, platelet activating factor and other cytokines have been studied for their impact on the in vitro fertilization capacity of spermatozoa. Intracytoplasmic sperm injection (ICSI) has provided infertile couples with hope for successful reproduction without sperm donation. The precise mechanism that allows subsequent pronuclear formation and syngamy is currently unknown and experimental models are few. Adjuvants that can be used in conjunction with controlled ovarian stimulation and intrauterine insemination are prominent areas for further research as this would provide an alternative to the expense and risks of in vitro fertilization and embryo transfer.

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