IMR Press / FBL / Volume 1 / Issue 5 / DOI: 10.2741/A143

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Immunoglobulin therapy in Kawasaki syndrome and RSV prophylaxis
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1 Department of Pediatrics, Floating Hospital for Children at New England Medical Center; Tufts University School of Medicine, Boston, MA 02111
2 Department of Pediatrics; The National Jewish Center for Immunology and Respiratory Medicine; Denver, CO 80262
Academic Editor:Kenth Gustafsson
Front. Biosci. (Landmark Ed) 1996, 1(5), 55–64; https://doi.org/10.2741/A143
Published: 1 August 1996
Abstract

Kawasaki syndrome and RSV infection are common illnesses that afflict infants and young children. Recent studies demonstrate that intravenous immunoglobulin (IVIG) treatment significantly reduces the clinical severity of these illnesses. The purpose of the current review will be initially to examine mechanisms of disease pathogenesis in KS and RSV infection. This will be followed by a discussion of the potential mechanisms by which IVIG acts in these two illnesses. In both KS and RSV prophylaxis, an important action by which IVIG may work is primarily through toxin or microbial neutralization resulting in the dampening or prevention of the inflammatory response. Other immunomodulatory actions of IVIG are likely to be operative in these diseases and will be an active area of future research.

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