IMR Press / FBE / Volume 8 / Issue 2 / DOI: 10.2741/E767

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer

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1 Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman
2 Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman

*Author to whom correspondence should be addressed.

Academic Editor: Allal Ouhtit

Front. Biosci. (Elite Ed) 2016, 8(2), 289–298; https://doi.org/10.2741/E767
Published: 1 January 2016
(This article belongs to the Special Issue Oxidative stress and cardiovascular diseases)
Abstract

BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors.

Keywords
BRIP1
BRCA1/2
Breast Cancer
Dna Damage Repair
Review
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