IMR Press / FBE / Volume 6 / Issue 1 / DOI: 10.2741/E696

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Can the response to mood stabilizers be predicted in bipolar disorder?
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1 INSERM, U955, Creteil, 94000, France
2 Psychiatry department, Lille Nord de France University, CHRU Lille, F-59000 Lille, France
3 AP-HP, H. Mondor - A. Chenevier, Psychiatry department, Creteil, 94000, France
4 FondaMental Foundation, Creteil, 94000, France
5 Paris Est University, Creteil, 94000, France
6 AP-HP, GH Saint-Louis - Lariboisiere - Fernand Widal, Neurosciences department, Paris, France
7 Paris-7 Paris-Diderot University, UFR Medecine, Paris, France

*Author to whom correspondence should be addressed.

Academic Editor: Bruno Etain

Front. Biosci. (Elite Ed) 2014, 6(1), 120–138; https://doi.org/10.2741/E696
Published: 1 January 2014
(This article belongs to the Special Issue Markers in bipolar disorders)
Abstract

Bipolar disorder (BD) is a severe chronic multifactorial disease that requires maintenance therapy with mood stabilizers (MS). Even with medications, the rate of response among patients with BD is low and the risk of relapse is high. Therefore, in this context of the urgent need for reliable and reproducible predictors of individual responses to MS, pharmacogenetics research is expected to provide helpful progress. Most pharmacogenetic studies of MS have focused on the response to lithium with several good putative candidate genes but informative results are sparse. There have been few studies on valproate, lamotrigine or atypical antipsychotics. Overall, the results of pharmacogenomics studies have not provided sufficient data to change daily practices in BD significantly and further investigation is warranted to identify highly relevant genetic predictors of response their roles. Although progress still remains to be made, the clinical assessment of a subject including the identification of specific individual phenotypic and pharmacogenetic characteristics is likely to become a powerful instrument for the development of personalized therapies.

Keywords
Bipolar disorder
Pharmacogenomics
Pharmacogenetics
Mood Stabilizer
Lithium
Review
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