IMR Press / FBE / Volume 5 / Issue 3 / DOI: 10.2741/E673

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Mouse models of chemically-induced lung carcinogenesis

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1 Department of Pharmacology and Toxicology, Medical College of Wisconsin and MCW Cancer Center, Milwaukee, WI, 53202, USA
Academic Editor:Alexander Sasha Krupnick
Front. Biosci. (Elite Ed) 2013, 5(3), 939–946; https://doi.org/10.2741/E673
Published: 1 June 2013
(This article belongs to the Special Issue Lung tissue engineering)
Abstract

Primary pulmonary malignancies remain the major source of cancer-related deaths in the Western World. While surgical resection is an efficacious therapy for those with early stage disease, the majority of patients present with advanced malignancies and systemic treatments, such as cytotoxic chemotherapy, have only limited efficacy in lung cancer. Furthermore, chemoprevention for current or former smokers has demonstrated only limited success using available agents. The mouse model of primary lung carcinogenesis represents a very valuable tool for the study of tumor initiation, promotion, and therapy. Here we discuss several models of chemically-induced murine lung cancer with a specific emphasis on translational and clinically-relevant lines of investigation. We emphasize the pros and cons of currently available models in order to facilitate further investigations into the development and treatment of primary pulmonary malignancies.

Keywords
Carcinogen
Adenoma
A/J strain
Chemoprevention
Review
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