IMR Press / FBE / Volume 5 / Issue 3 / DOI: 10.2741/E668

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Can triggered arrhythmias arise from propagation of Ca2+ waves between cardiac cells?

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1 Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

*Author to whom correspondence should be addressed.

Academic Editor: Rosana Bassani

Front. Biosci. (Elite Ed) 2013, 5(3), 893–899; https://doi.org/10.2741/E668
Published: 1 June 2013
(This article belongs to the Special Issue Calcium and the heart: signaling and regulation)
Abstract

Intracellular Ca2+ overload can induce regenerative Ca2+ waves that activate inward current in cardiac myocytes, allowing the cell membrane to achieve threshold. The result is a triggered extrasystole that can, under the right conditions, lead to sustained triggered arrhythmias. In this review, we consider the issue of whether or not Ca2+ waves can travel between neighboring myocytes and if this intercellular Ca2+ diffusion can involve enough cells over a short enough period of time to actually induce triggered activity in the heart. This review is not intended to serve as an exhaustive review of the literature summarizing Ca2+ flux through cardiac gap junctions or of how Ca2+ waves move from cell to cell. Rather, it summarizes many of the pertinent experimental studies and considers their results in the theoretical context of whether or not the intercellular propagation of Ca2+ overload can contribute to triggered beats and arrhythmias in the intact heart.

Keywords
Calcium Waves
Arrhythmias
Delayed Afterdepolarizations
Intracellular Calcium Overload
Review
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