IMR Press / FBE / Volume 4 / Issue 5 / DOI: 10.2741/e488

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


LINE-1: creators of neuronal diversity

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1 Department of Pediatrics, Rady Children’s Hospital San Diego and Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093

*Author to whom correspondence should be addressed.

Academic Editor: Kathleen Burns

Front. Biosci. (Elite Ed) 2012, 4(5), 1663–1668;
Published: 1 January 2012
(This article belongs to the Special Issue Mobile DNAs in mammalian genomes)

Long interspersed nucleotide element 1 (L1) is a family of non-LTR retrotransposons that can replicate and reintegrate into the host genome. L1s have considerably influenced mammalian genome evolution by retrotransposing during germ cell development or early embryogenesis, leading to massive genome expansion. In humans, over 30% of the genome can be attributed to L1- mediated retrotransposition. Historically, L1s were thought to only retrotranspose during gametogenesis and in neoplastic processes, but recent studies have shown that L1s are extremely active in the mouse, rat, and human neuronal progenitor cells (NPCs). In fact, it is estimated that the hippocampus and other regions of the brain may have multiple insertions per cell. These insertions can dramatically impact neuronal transcriptional expression, creating unique transcriptomes of individual neurons. Furthermore, transcriptional activation of L1 elements mimics the transcription activation of the NeuroD1 gene, suggesting a prominent role of L1 expression during neurogenesis.

Neuronal Diversity
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