IMR Press / FBE / Volume 4 / Issue 4 / DOI: 10.2741/e462

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Size matters: smart copolymeric nanohydrogels: synthesis and applications

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1 Grupo de Nuevos Materiales y Espectroscopia Supramolecular, Facultad de Ciencia y Tecnologia. Campus de Leioa, Spain
2 Departamento de Quimica, CUCEI, Universidad de Guadalajara, Boulevard Marcelino Garcia Barragan 1451, Jalisco, Mexico

*Author to whom correspondence should be addressed.

Academic Editor: Pablo Taboada

Front. Biosci. (Elite Ed) 2012, 4(4), 1314–1334;
Published: 1 January 2012
(This article belongs to the Special Issue Polymeric nanostructures for drug delivery)

In this work the synthesis of smart nanoparticles capable of respond to external stimulus (pH and temperature variations) is reported. To avoid postpolymerization modification, functionalized monomers able to respond to pH and temperature changes were and then polymerized. The synthesized monomers have the capability for coupling with folic acid which is the target molecule. For this reason their polymers can be used as targeted drug delivery systems. Smart polymeric nanoparticles were prepared by direct and inverse microemulsion polymerization of the synthesized monomers. The nanoparticles were charged with drugs and their release kinetic was studied.

Smart Nanohydrogels
Cancer Therapy
Drug Release
pH-sensitive gels
T-Sensitive Gels
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