IMR Press / FBE / Volume 4 / Issue 3 / DOI: 10.2741/e448

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review

Hepatocellular carcinoma stem cells: origins and roles in hepatocarcinogenesis and disease progression

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1 Department of Medical Microbiology, Immunology, and Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine. 913 N. Rutledge Street, Springfield, IL 62794, USA

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Elite Ed) 2012, 4(3), 1157–1169; https://doi.org/10.2741/e448
Published: 1 January 2012
Abstract

Hepatocellular carcinoma (HCC) is a treatmentresistant malignancy with an increasing incidence worldwide. More than 500,000 individuals suffer from this disease annually. Risk factors for human HCC include hepatitis B and C infections, dietary aflatoxin, alcohol abuse, smoking, and oral contraceptive use. Accumulating evidence suggests that liver stem cells play a critical role in HCC development and progression. Dedifferentiated hepatocytes, hepatic oval cells and bone marrow cells are the three major types of liver stem cells, and CD133, CD90, and EpCAM are identified as specific antigenic markers for HCC stem cells. Wnt, Hedgehog, and the angiogenic signalings are main pathways that regulate the HCC stem cell self-renewal and pluripotential, and may be potential targets for novel therapeutic strategies of this malignancy. This review article provides an update in the studies of live and HCC stem cells.

Keywords
Cancer stem cells
Hepatocellular Carcinoma
Hepatocyte
Liver Development
Liver Regeneration
Oval Cell
Bone Marrow Cell
Hepatocarcinogenesis
Hepatic Progenitor Cell
VEGF Angiogenic Signaling
Wnt/betacatenin pathway
and Hedgehog Signaling
Cancer Therapy
Review
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