IMR Press / FBE / Volume 4 / Issue 2 / DOI: 10.2741/e406

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


SP-A and SP-D in host defense against fungal infections and allergies

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1 National Institute for Research in Reproductive Health, Mumbai, India
2 Centre for Infection, Immunity and Disease Mechanisms, Biosciences, School of Health Sciences and Social Care, Brunel University, London, UK

*Author to whom correspondence should be addressed.

Academic Editor: Uday Kishore

Front. Biosci. (Elite Ed) 2012, 4(2), 651–661;
Published: 1 January 2012
(This article belongs to the Special Issue Pulmonary surfactant in human health and disease)

Innate immunity mediated by pattern recognition proteins is relevant in the host defense against fungi. SP-A and SPD are two such proteins belonging to the class of collagen domain containing C-type lectins, or collectins. They bind to the sugar moieties present on the cell walls of various fungi in a dose dependent manner via their carbohydrate recognition domain (CRD). SP-A and SP-D directly interact with alveolar macrophages, neutrophils, lymphocytes. We review these roles of SP-A and SP-D against various clinically relevant fungal pathogens and fungal allergens. SP-A and SP-D gene deficient mice showed increased susceptibility/ resistance to various fungal infections. Patients of fungal infections and allergies are reported with alterations in the serum or lung lavage levels of SP-A and SP-D. There are studies associating the gene polymorphisms in SP-A and SP-D with alterations in their levels or functions or susceptibility of the host to fungal diseases. In view of the protective role of SP-D in murine models of Aspergillus fumigatus infections and allergies, therapeutic use of SP-D could be explored further.

host defense
A. fumigatus
fungal infection
innate immune system
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