IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e399

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Dietary supplements and natural products in breast cancer trials

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1 Wayne State University School of Medicine, 540 E. Canfield Detroit, MI 48201
2 Michigan State University College of Osteopathic Medicine, 4707 St. Antoine, Detroit, MI 48201

*Author to whom correspondence should be addressed.

Academic Editor: Mukesh Agarwal

Front. Biosci. (Elite Ed) 2012, 4(1), 546–567;
Published: 1 January 2012
(This article belongs to the Special Issue Novel strategies for detection, prevention and treatment of cancer)

The association between breast cancer and modifiable health behaviors is well supported. At least onehalf of all cancers are suggested to have a dietary component. It is not surprising therefore that many of the dietary agents and natural health products that have attracted the attentions of scientists and practitioners are now moving into clinical trials. In this report, we review 65 clinical intervention trials evaluating over 30 dietary supplements and natural health products for use in breast cancer. The products being tested in these trials fall broadly into the following categories: (i) vitamins, minerals, cofactors; (ii) herbal extracts; (iii) amino acids; (iv) fatty acids; (v) animal products; (vi) probiotics; (vii) phytochemicals; and (viii) combination formulations. Trial outcome measures include risk modification, efficacy testing (with dietary supplements alone or dietary supplementanticancer drug combinations), toxicity reduction, biomarker identification, symptom management, and quality of life parameters. The wide range of interests in natural product testing at the clinical trial level supports the potential utility of these agents in the breast cancer prevention, treatment, and management regimens of the future.

Dietary supplements
natural health products
clinical trials
breast cancer
vitamins and minerals
vitamin D
mistletoe extract
Iscador P
grapeseed extract
coriolus vesicolor
scutellaria barbata
natural health product-chemotherapy combinations
endocrine therapy
complementary-conventional therapy combinations
green tea polyphenols
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