IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e396

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Sialyltransferases functions in cancers

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1 Univ Lille Nord de France, F-59000 Lille, France, USTL, UGSF, IFR 147, F-59650 Villeneuve d’Ascq, France, CNRS UMR 8576, F-59650 Villeneuve d’Ascq, France

*Author to whom correspondence should be addressed.

Academic Editor: Hafiz Ahmed

Front. Biosci. (Elite Ed) 2012, 4(1), 499–515; https://doi.org/10.2741/e396
Published: 1 January 2012
(This article belongs to the Special Issue Glycobiology of cancer)
Abstract

Abnormally elevated levels of sialylated tumor associated carbohydrate antigens are frequently described at the surface of cancer cells and/or secreted in biological fluids. It is now well established that this over-expression may result from deregulation in sialyltransferases enzymatic activity involved in their biosynthesis, but the precise molecular mechanisms remain unknown. Twenty different human sialyltransferases preside to the sialylation of glycoconjugates, either glycolipids or glycoproteins. This review summarizes the current knowledge on human sialyltransferases implicated in the altered expression of sialylated tumor associated antigens, the molecular basis of their regulated expression in cancer cells and the various tools developed by researchers and clinicians for their study in pathological samples.

Keywords
Cancer
sialyltransferase
Golgi
sialylation Review
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