IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e393

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review

Activation of Wnt and Myc signaling in hepatoblastoma

Show Less
1 XenTech, 4 rue Pierre Fontaine, 91000 Evry, France
2 Health Sciences Research Institute, Germans Trias i Pujol Foundation, CIBERehd, Hepatology Unit, C/ Cami de les escoles, s/n, 08916 Badalona, Barcelona, Spain
3 Institut Pasteur, Oncogenesis and Molecular Virology Unit, Virology Department, Inserm U579, 28 rue du Dr Roux, 75015 Paris, France

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Elite Ed) 2012, 4(1), 480–486; https://doi.org/10.2741/e393
Published: 1 January 2012
Abstract

Hepatoblastoma (HB) is the most common type of pediatric liver cancer. This tumor is thought to derive from hepatic progenitor cells that are arrested at various stages of liver development, as illustrated by a variety of histologic subtypes. Recent genomic studies have led to better understand the molecular pathogenesis of HB, to point out the crucial roles of the Wnt Myc signaling pathways in malignant transformation of liver progenitor cells. Molecular classification of HB based on genomewide studies, as well as identification of reliable diagnostic prognostic markers, open the way to the development of new personalized targeted therapies for the management of aggressive lethal childhood tumors.

Keywords
Molecular Biology
Genomics
Proteomics
Cancer
Liver
Pediatric
Beta-Catenin
Myc
Review
Share
Back to top