IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e386

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Tissue factor pathway inhibitor as a multifunctional mediator of vascular structure

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1 Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905

*Author to whom correspondence should be addressed.

Academic Editor: L. Vijaya Mohan Rao

Front. Biosci. (Elite Ed) 2012, 4(1), 392–400; https://doi.org/10.2741/e386
Published: 1 January 2012
Abstract

Tissue factor pathway inhibitor (TFPI) is a potent regulator of tissue factor – factor VII-dependent activation of the tissue factor pathway. TFPI is a serine protease inhibitor that contains three Kunitz domains and a basic carboxyl terminus. TFPI is primarily expressed on endothelial cells, and murine models have demonstrated that its expression regulates vascular thrombosis. The localization of TFPI expression and the requirement for TFPI in development suggest a potential role in regulating vascular structure. Data from animal studies suggest that vascular expression of TFPI inhibits pathologic vascular remodeling and inhibits angiogenesis. The mechanism for these effects is diverse and includes tissue factor and factor Xa-dependent and -independent mechanisms.

Keywords
Tissue factor
Atherosclerosis
Angiogenesis
Review
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