IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e383

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Tissue factor in health and disease

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1 Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, North Carolina

*Author to whom correspondence should be addressed.

Academic Editor: L. Vijaya Mohan Rao

Front. Biosci. (Elite Ed) 2012, 4(1), 358–372; https://doi.org/10.2741/e383
Published: 1 January 2012
Abstract

Tissue Factor (TF) is a crucial initiator of the extrinsic coagulation cascade. TF is expressed on cells which are normally sequestered from blood. However, upon injury TF is exposed to the blood resulting in activation of the coagulation cascade. TF dependent generation of coagulation proteases also initiates intracellular signaling through protease activated receptors. Pathologic TF expression is found in patients with a number of different diseases. This review will describe the roles of TF in health and disease as well as discuss approaches to reduce pathologic TF expression.

Keywords
Tissue Factor
Protease Activated Receptors
Pregnancy
Infection
Cardiovascular Disease
Thrombosis
Cancer
Sickle Cell Disease
Diabetes
Review
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