IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e364

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Hyponatremia and hypernatremia in the newborn: in medio stat virtus

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1 Department of Pediatrics, Section of Neonatal Intensive Care Unit, University of Cagliari, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Diego Gazzolo

Front. Biosci. (Elite Ed) 2012, 4(1), 132–140;
Published: 1 January 2012
(This article belongs to the Special Issue Clinical and biochemical markers and fetal-neonatal development)

Hyponatremia and hypernatremia are complex clinical problems that occur frequently in full term newborns and in preterm infants admitted to the Neonatal Intensive Care Unit (NICU) although their real frequency and etiology are incompletely known. Pathogenetic mechanisms and clinical timing of hypo-hypernatremia are well known in adult people whereas in the newborn is less clear how and when hypo-hypernatremia could alter cerebral osmotic equilibrium and after how long time brain cells adapt themselves to the new hypo-hypertonic environment. Aim of this review is to present a practical approach and management of hypo-hypernatremia in newborns, especially in preterms.

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