IMR Press / FBE / Volume 3 / Issue 4 / DOI: 10.2741/E341

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Charting the peptide crossreactome between HIV-1 and the human proteome
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1 Department of Biochemistry and Molecular Biology,Ernesto Quagliariello, University of Bari, Bari, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Darja Kanduc

Front. Biosci. (Elite Ed) 2011, 3(4), 1385–1400; https://doi.org/10.2741/E341
Published: 1 June 2011
(This article belongs to the Special Issue Peptides: from basic research to clinical applications)
Abstract

This paper defines potential peptide cross-reactivity between HIV-1 and the human host. Specifically, the amino acid primary sequence of HIV-1, isolate CDC-451, was analyzed for potential immunopathological relationships with the human proteome. The results revealed that: 1) HIV-1 shares 50 heptapeptides and three octapeptides with the human proteome; 2) 34 of the 50 shared heptapeptides are experimentally validated epitopes targeted by immune responses following HIV-1 infection; 3) the viral heptapeptide epitopes are present in human proteins that, when altered, are associated with disease characteristics of acquired immunodeficiency syndrome (AIDS) such as CD4+ cell loss, encephalopathy, schizophrenia, myopathy, cardiovascular disorders, hypertension, corneal diseases, diarrhea, lymphoma, and bladder cancer; 4) at the pentapeptide level, the viral-versus-human overlap is extensive (14,227 matches), with the viral pentapeptides disseminated throughout 10,312 human proteins. The findings are discussed in relationship to HIV-1 escape from immune surveillance, adjuvant-induced HIV-1 immunogenicity, autoimmune cross-reactions following human hyperimmune responses against HIV-1, and AIDS.

Keywords
HIV-1 proteome
human proteome
HIV-vshuman crossreactome
HIV-derived epitopes
HIV escape from immune surveillance
adjuvant-induced immune activation
crossreactivity-induced AIDS
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