IMR Press / FBE / Volume 3 / Issue 4 / DOI: 10.2741/E329

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Optimal cut-off values for tumor markers in cerebrospinal fluid with ROC curve analysis
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1 Department of Neurology, General Hospital of PLA, Beijing 100853, China
2 Department of medical statistics, General Hospital of PLA, Beijing 100853, China

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2011, 3(4), 1259–1264; https://doi.org/10.2741/E329
Published: 1 June 2011
Abstract

To select optimal cut-off values of tumor markers in cerebrospinal fluid for the diagnosis of meningeal carcinomatosis, the concentrations of CEA, CA125, CA153, CA199, CA724, CYFRA21-1, AFP and NSE were determined by means of double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) in 21 MC patients, 25 cancer patients without leptomeningeal disease (group one) and 45 meningitis patients (group two) using the Roche E170 modular immunoassay analyzer. Optimal cut-off values were selected based on a receiver-operating characteristic curve. The results showed that CA125 and CEA in CSF were optimal diagnostic indices distinguishing between MC patients and cancer patients without leptomeningeal disease. Cut-off values for CA125 and CEA were 1.715 µ/ml and 0.274 µg/l, respectively. In addition, CEA in CSF was the optimal diagnostic index distinguishing MC patients from meningitis patients. The cut-off value for CEA was 4.522 µg/l.

Keywords
Tumor markers
Receiver-operating characteristic curve
Cerebrospinal fluid
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