IMR Press / FBE / Volume 3 / Issue 3 / DOI: 10.2741/E320

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Principles, applications, risks and benefits of therapeutic hyperthermia
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1 McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada
2 Department of Electrical and Computer Engineering, University of Connecticut, Connecticut, USA
3 College of Engineering and Applied Sciences, Al Ghurair University, Dubai, UAE

*Author to whom correspondence should be addressed.

Academic Editor: Clark Blatteis

Front. Biosci. (Elite Ed) 2011, 3(3), 1169–1181; https://doi.org/10.2741/E320
Published: 1 June 2011
(This article belongs to the Special Issue Frontiers in thermoregulation research)
Abstract

Hyperthermia as a heat therapy is the procedure of raising the temperature of a part of or the whole body above normal for a certain period of time. Based largely on delivery methods, therapeutic hyperthermia falls under three major categories: local, regional, and whole-body. It may be applied alone or jointly with other modalities such as radiotherapy, chemotherapy, radiochemotherapy, and gene therapy. Because of the individual characteristics of each type of treatment, different types of heating systems have evolved. This paper provides an overview of possible mechanisms of heat-induced cell death and the way heating exerts its beneficial effect. It also discusses various heating devices as well as other modalities used with hyperthermia. The paper concludes with a summary of benefits and risks, obstacles encountered in the treatment process, and future research directions.

Keywords
Hyperthermia
Heating techniques
Treatment modalities
Treatment planning
Benefits and risks
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