IMR Press / FBE / Volume 3 / Issue 3 / DOI: 10.2741/E302

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
C-Myb function in the vessel wall
Show Less
1 Cardiovascular Research Group, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK

*Author to whom correspondence should be addressed.

Academic Editor: Tao Wang

Front. Biosci. (Elite Ed) 2011, 3(3), 968–977; https://doi.org/10.2741/E302
Published: 1 June 2011
(This article belongs to the Special Issue Signalling pathways in cardiovascular function and diseases)
Abstract

C-Myb is a DNA-binding transcription factor that functions in apoptosis, proliferation and differentiation. The role of c-Myb in vascular injury has been investigated previously both in vitro and in vivo, where knock-down of c-Myb is known to lead to a reduction in proliferation and an increase in apoptosis of vascular smooth muscle cells (VSMCs). Reduction of c-Myb activity has also been shown to decrease neointimal formation in vivo, by reducing VSMC proliferation. In contrast, over-expression of c-Myb in vivo leads to increased survival rates in certain cell types. This review will look mainly at studies investigating c-Myb function in the vasculature, and evidence of signalling interactions which may be considered with regard to c-Myb as a possible target in the treatment of vasculoproliferative diseases.

Keywords
c-Myb
apoptosis
proliferation
atherosclerosis
angioplasty
neointima
smooth muscle
knock-down
antisense
Myb Engrailed
Review
Share
Back to top