IMR Press / FBE / Volume 2 / Issue 4 / DOI: 10.2741/E205

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Biomarkers of corticosteroid-induced hypertrophic cardiomyopathy in preterm babies
Show Less
1 Department of Cardiovascular and Neurological Sciences, University of Cagliari, Cagliari, Italy
2 Research Laboratory Department of Cardiac Surgery San Donato Milanese University, San Donato, Italy
3 Department of Pediatrics and Clinical Medicine, Section of Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy
Front. Biosci. (Elite Ed) 2010, 2(4), 1460–1471;
Published: 1 June 2010

The study of biomarkers and their signaling pathways has led to the development of new therapeutic strategies in a number of disorders. The purpose of the present systematic review is to provide an overview of different biomarkers in preterm newborns with corticosteroid-induced hypertrophic cardiomyopathy (CCHC). Several pathophysiological biomarkers are presented and discussed with the aim of investigating their diagnostic and prognostic value, particularly in relation to the potential progression of the disease and/or mortality in adulthood. This investigative approach may not only provide pathophysiological information on this serious drug-induced adverse effect, but also suggest novel therapeutic approaches to be applied in controlling its harmful consequences.

Back to top