IMR Press / FBE / Volume 2 / Issue 4 / DOI: 10.2741/E191

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mechanisms of microRNA-mediated regulation of angiogenesis
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1 Department of Anesthesiology of Huashan Hospital, Fudan University, Shanghai 200032, China
2 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai 200032, China
3 Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Academic Editor:Feng Zhang
Front. Biosci. (Elite Ed) 2010, 2(4), 1304–1319; https://doi.org/10.2741/E191
Published: 1 June 2010
Abstract

Stroke is the second most common cause of death and consumes about 2-4% of total health-care costs worldwide. Although most studies have focused on neuroprotection during the past decades, current therapeutic options are still very limited. Recently scientists have intensified their work on neurorestorative therapies, including angiogenesis, which allow a far greater time window for improving neurological recovery. MicroRNAs have emerged as crucial players, regulating almost every cellular process investigated to date, and evidence of their role in the context of angiogenesis and stroke has been rapidly accumulating. The goal of this review is to summarize the mechanisms of microRNA-mediated regulation of angiogenesis and the implications for a novel molecular approach to enhance neurological recovery after stroke.

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